发明授权
US08388821B2 Method for determining hematocrit corrected analyte concentrations
有权
确定血细胞比容校正分析物浓度的方法
- 专利标题: Method for determining hematocrit corrected analyte concentrations
- 专利标题(中): 确定血细胞比容校正分析物浓度的方法
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申请号: US12305363申请日: 2007-10-05
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公开(公告)号: US08388821B2公开(公告)日: 2013-03-05
- 发明人: Stephen Patrick Blythe , Marco F. Cardosi , Andrew Gill , Leanne Mills , Christopher Philip Leach
- 申请人: Stephen Patrick Blythe , Marco F. Cardosi , Andrew Gill , Leanne Mills , Christopher Philip Leach
- 申请人地址: GB
- 专利权人: LifeScan Scotland Limited
- 当前专利权人: LifeScan Scotland Limited
- 当前专利权人地址: GB
- 国际申请: PCT/GB2007/003770 WO 20071005
- 国际公布: WO2008/040982 WO 20080410
- 主分类号: G01N27/327
- IPC分类号: G01N27/327
摘要:
Description is provided herein for an embodiment of a method determining a hematocrit-corrected glucose concentration. The exemplary method includes providing a test strip having a reference electrode and a working electrode, wherein the working electrode includes a plurality of microelectrodes and is coated with at least an enzyme and a mediator. The method can be achieved by: providing a test strip comprising a reference electrode and a working electrode formed with a plurality of microelectrodes and coated with a reagent layer; applying a fluid sample to the test strip for a reaction period; applying a test voltage between the reference electrode and the working electrode; measuring a test current as a function of time; measuring a steady state current value when the test current has reached an equilibrium; calculating a ratio of the test current to the steady state current value; plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time; calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time; and calculating a hematocrit-corrected concentration of analyte.