发明授权
US08389507B2 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as TAAR-ligands
失效
2-氮杂环丁烷甲烷胺和2-吡咯烷甲烷胺作为TAAR-配体
- 专利标题: 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as TAAR-ligands
- 专利标题(中): 2-氮杂环丁烷甲烷胺和2-吡咯烷甲烷胺作为TAAR-配体
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申请号: US12176456申请日: 2008-07-21
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公开(公告)号: US08389507B2公开(公告)日: 2013-03-05
- 发明人: Guido Galley , Annick Goergler , Katrin Groebke Zbinden , Roger Norcross , Henri Stalder
- 申请人: Guido Galley , Annick Goergler , Katrin Groebke Zbinden , Roger Norcross , Henri Stalder
- 申请人地址: US NJ Nutley
- 专利权人: Hoffmann-La Roche Inc.
- 当前专利权人: Hoffmann-La Roche Inc.
- 当前专利权人地址: US NJ Nutley
- 代理商 George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- 优先权: EP07113329 20070727
- 主分类号: A01N43/00
- IPC分类号: A01N43/00 ; A61K31/397
摘要:
The present invention relates to compounds of formula I wherein R1, R2, R3, Ar, n and o are as defined herein and to their pharmaceutically acceptable active salts. Compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1 and are useful for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
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