发明授权
US08394787B2 7-aza-spiro[3.5]nonane-7-carboxylate derivatives, preparation thereof and therapeutic use thereof
有权
7-氮杂螺[3.5]壬烷-7-羧酸酯衍生物,其制备及其治疗用途
- 专利标题: 7-aza-spiro[3.5]nonane-7-carboxylate derivatives, preparation thereof and therapeutic use thereof
- 专利标题(中): 7-氮杂螺[3.5]壬烷-7-羧酸酯衍生物,其制备及其治疗用途
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申请号: US13320199申请日: 2010-05-11
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公开(公告)号: US08394787B2公开(公告)日: 2013-03-12
- 发明人: Ahmed Abouabdellah , Nathalie Chereze , Aude Fayol , Alistair Lochead , Mourad Saady , Julien Vache , Philippe Yaiche
- 申请人: Ahmed Abouabdellah , Nathalie Chereze , Aude Fayol , Alistair Lochead , Mourad Saady , Julien Vache , Philippe Yaiche
- 申请人地址: FR Paris
- 专利权人: Sanofi
- 当前专利权人: Sanofi
- 当前专利权人地址: FR Paris
- 代理机构: Scully, Scott, Murphy & Presser, P.C.
- 优先权: FR0902269 20090512
- 国际申请: PCT/FR2010/050914 WO 20100511
- 国际公布: WO2010/130945 WO 20101118
- 主分类号: A61K31/397
- IPC分类号: A61K31/397 ; C07D205/12 ; C07D263/30 ; C07D261/06 ; C07D221/20 ; A61K31/422 ; A61K31/421 ; A61K31/438
摘要:
The invention relates to compounds of the general formula (I) where: R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, or NR8R9 group; m, n, o and p independently are a number from 0 to 3, provided that m+n≦7 and that o+p≦7; A is a covalent bond, an oxygen atom, a C1-6-alkylene group or a —O—C1-6-alkylene group in which the end that is an oxygen atom is bonded to the R1 group and the end that is an alkylene group is bonded to the carbon of the bicyclic compound; R1 is an optionally substituted aryl or heteroaryl group; R3 is a hydrogen or fluorine atom or a C1-6-alkyl or trifluoromethyl group; R4 is an optionally substituted 5-membered heterocyclic compounds; wherein the compounds can be in the state of a base or an acid addition salt. The invention can be used in therapeutics.
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