发明授权
US08394837B2 2,3,4,6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
有权
用作治疗阿尔茨海默氏病的β-分泌酶抑制剂的2,3,4,6-取代的吡啶衍生物化合物
- 专利标题： 2,3,4,6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
- 专利标题（中）： 用作治疗阿尔茨海默氏病的β-分泌酶抑制剂的2,3,4,6-取代的吡啶衍生物化合物
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申请号： US11791204申请日： 2005-11-18
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公开(公告)号： US08394837B2公开(公告)日： 2013-03-12
- 发明人: Philippe G. Nantermet , Hemaka A. Rajapakse , Harold G. Selnick , James C. Barrow , Shaun R. Stauffer , Joseph P. Vacca , Keith P. Moore , Shawn J. Stachel , Mattahew G. Stanton
- 申请人： Philippe G. Nantermet , Hemaka A. Rajapakse , Harold G. Selnick , James C. Barrow , Shaun R. Stauffer , Joseph P. Vacca , Keith P. Moore , Shawn J. Stachel , Mattahew G. Stanton
- 申请人地址： US NJ Rahway
- 专利权人： Merck, Sharp & Dohme, Corp.
- 当前专利权人： Merck, Sharp & Dohme, Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Keith D. MacMillan; Gerard M. Devlin
- 国际申请： PCT/US2005/042087 WO 20051118
- 国际公布： WO2006/057945 WO 20060601
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; C07D413/04
摘要：
The present invention is directed to 2,3,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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