Invention Grant
US08394839B2 Rationally improved isoniazid and ethionamide derivatives and activity through selective isotopic substitution
有权
通过选择性同位素替代，合理改善异烟肼和乙硫异烟酰胺衍生物和活性
- Patent Title: Rationally improved isoniazid and ethionamide derivatives and activity through selective isotopic substitution
- Patent Title (中): 通过选择性同位素替代，合理改善异烟肼和乙硫异烟酰胺衍生物和活性
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Application No.: US12674188Application Date: 2008-08-20
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Publication No.: US08394839B2Publication Date: 2013-03-12
- Inventor: Graham Timmins , Vojo P Deretic
- Applicant: Graham Timmins , Vojo P Deretic
- Applicant Address: US NM Albuquerque US MD Baltimore
- Assignee: STC.UNM,The John Hopkins University
- Current Assignee: STC.UNM,The John Hopkins University
- Current Assignee Address: US NM Albuquerque US MD Baltimore
- Agent Henry D. Coleman; R. Neil Sudol; William J. Sapone
- International Application: PCT/US2008/009909 WO 20080820
- International Announcement: WO2009/025820 WO 20090226
- Main IPC: A61K31/4409
- IPC: A61K31/4409 ; C07D213/86
Abstract:
The present invention relates to the use of isotopically labeled derivatives of isoniazid, ethionamide and related compounds as effective therapy for the treatment of mycobacterial diseases, including Mycobacterium tuberculosis.
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