发明授权
- 专利标题： Chemical linkers and conjugates thereof
- 专利标题（中）： 化学接头及其共轭物
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申请号： US12610952申请日： 2009-11-02
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公开(公告)号： US08399403B2公开(公告)日： 2013-03-19
- 发明人: Sharon E. Boyd , Liang Chen , Sanjeev Gangwar , Vincent Guerlavais , Kilian Horgan , Zhi-Hong Li , Bilal Sufi
- 申请人： Sharon E. Boyd , Liang Chen , Sanjeev Gangwar , Vincent Guerlavais , Kilian Horgan , Zhi-Hong Li , Bilal Sufi
- 申请人地址： US NJ Princeton
- 专利权人： Medarex, Inc.
- 当前专利权人： Medarex, Inc.
- 当前专利权人地址： US NJ Princeton
- 代理机构： Nelson Mullins Riley & Scarborough LLP
- 代理商 Jane E. Remillard, Esq.; Pankaj N. Desai
- 主分类号： A61K38/00
- IPC分类号： A61K38/00
摘要：
The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
公开/授权文献
- US20100092496A1 CHEMICAL LINKERS AND CONJUGATES THEREOF 公开/授权日：2010-04-15
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