发明授权
- 专利标题： Template-fixed peptidomimetics
- 专利标题（中）： 模板固定肽模拟物
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申请号： US12528926申请日： 2007-02-28
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公开(公告)号： US08399611B2公开(公告)日： 2013-03-19
- 发明人: Daniel Obrecht , Frank Gombert , Steven J. Demarco , Christian Ludin , Jan Wim Vrijbloed , Kerstin Moehle , John-Anthony Robinson , Reshmi Mukherjee , Heiko Henze , Barbara Romagnoli
- 申请人： Daniel Obrecht , Frank Gombert , Steven J. Demarco , Christian Ludin , Jan Wim Vrijbloed , Kerstin Moehle , John-Anthony Robinson , Reshmi Mukherjee , Heiko Henze , Barbara Romagnoli
- 申请人地址： CH Allschwil CH Zurich
- 专利权人： Polyphor Ltd.,Universitaet Zuerich
- 当前专利权人： Polyphor Ltd.,Universitaet Zuerich
- 当前专利权人地址： CH Allschwil CH Zurich
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 国际申请： PCT/CH2007/000101 WO 20070228
- 国际公布： WO2008/104090 WO 20080904
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; A61K38/10 ; A61K38/04
摘要：
The template-fixed β-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-DPro-Pro), disulfide bond between Cys4 and Cys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or for treating inflammation, or, in particular, for stem cell mobilization of peripheral blood stem cells and/or mesenchymal stem cell (MSC) and/or other stem cells which retention depend on the CXCR4-receptor.
公开/授权文献
- US20100048463A1 TEMPLATE-FIXED PEPTIDOMIMETICS 公开/授权日：2010-02-25