发明授权
- 专利标题： O-acyloxime derivatives, preparation method thereof, and pharmaceutical composition containing the same for prevention and treatment of cardiovascular disease
- 专利标题（中）： O-酰肟衍生物，其制备方法和含有该组合物的预防和治疗心血管疾病的药物组合物
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申请号： US12614634申请日： 2009-11-09
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公开(公告)号： US08399662B2公开(公告)日： 2013-03-19
- 发明人: Tae-Sook Jeong , Woo-Song Lee , Hyung-Jae Jeong , Yong-Dae Park , Jong-Min Han , Hyoung-Chin Kim , Og-Sung Moon , Young-Suk Won
- 申请人： Tae-Sook Jeong , Woo-Song Lee , Hyung-Jae Jeong , Yong-Dae Park , Jong-Min Han , Hyoung-Chin Kim , Og-Sung Moon , Young-Suk Won
- 申请人地址： KR Daejeon
- 专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人地址： KR Daejeon
- 代理机构： Lucas & Mercanti, LLP
- 优先权： KR10-2004-0092263 20041112
- 主分类号： C07D295/10
- IPC分类号： C07D295/10 ; C07D333/38 ; C07C229/00
摘要：
The present invention relates to novel O-acyloxime derivatives, a preparation method thereof and a pharmaceutical composition comprising the same for prevention and treatment of cardiovascular disease.The O-acyloxime derivatives according to the present invention may valuably be used for prevention and treatment of cardiovascular diseases such as hyperlipidemia, coronary arterial heart disease, atherosclerosis, and myocardial infarction caused by Lp-PLA2, because they have excellent inhibitory effect of Lp-PLA2.