The invention provides an integrated framework for detecting peripheral sympathetic responses through imaging. The measurements may be performed on three facial areas of sympathetic importance, that is, periorbital, supraorbital, and maxillary. Because the imaging measurements are thermal in nature and comprise multiple components of variable frequency (i.e., blood flow, sweat gland activation, and breathing), wavelets are used as the image analysis framework. The image analysis may be grounded on GSR signals.