- 专利标题： MicroRNA as a cancer progression predictor and its use for treating cancer
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申请号： US13074719申请日： 2011-03-29
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公开(公告)号： US08404437B2公开(公告)日： 2013-03-26
- 发明人: Shih-Hwa Chiou , Guang-Yuh Chiou
- 申请人： Shih-Hwa Chiou , Guang-Yuh Chiou
- 申请人地址： TW Taipei
- 专利权人： Taipei Veterans General Hospital
- 当前专利权人： Taipei Veterans General Hospital
- 当前专利权人地址： TW Taipei
- 代理机构： Volpe and Koenig, P.C.
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C07H21/02 ; C07H21/04
摘要：
The present invention is based on the findings that a novel function for miR142-3p in the regulation of Sox2, adenylyl cyclase 9 (AC9), and CD133 expressions, and consequently the overall stemness of recurrent GBM cells as well as CSCs, and that miR142-3p modulated tumor-initiating properties in recurrent GBM. The present invention consequently supports the development of novel miRNA-based strategies for brain tumor treatment.
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