发明授权
- 专利标题: Polypeptides KXK and their use
- 专利标题(中): 多肽KXK及其用途
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申请号: US12224032申请日: 2006-02-16
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公开(公告)号: US08404648B2公开(公告)日: 2013-03-26
- 发明人: Karl Lintner , Olivier Peschard , Philippe Mondon , Claire Mas Chamberlin
- 申请人: Karl Lintner , Olivier Peschard , Philippe Mondon , Claire Mas Chamberlin
- 申请人地址: FR
- 专利权人: Sederma
- 当前专利权人: Sederma
- 当前专利权人地址: FR
- 代理机构: Lerner, David, Littenberg, Krumholz & Mentlik, LLP
- 国际申请: PCT/IB2006/001436 WO 20060216
- 国际公布: WO2007/093839 WO 20070823
- 主分类号: A61K38/07
- IPC分类号: A61K38/07 ; A61P17/00
摘要:
The invention concerns polypeptides of the general formula (I): A-(Xaa)n-Lys-X-Lys-B wherein: i) A is —NH2, NH3+, or NH-D (D is an acyl group being biotin or an alkyl chain (C2-C22)), H) B is H, O−OR1 or NR2R3 and R1, R2 and R3 independently either: H or an alkyl chain (C1-C24), iii) (Xaa)n is an amino acid chain including any amino acid natural or not, excluding arginine and lysine, iv) “n” is between 0-3, and v) X is either a chain of two any amino acids (Xaa1Xaa2) which may be the same or different, excluding arginine, lysine and excluding Xaa1Xaa2=Thr-Thr, Gly-His and Glu-His, or X is a spacer selected among beta-alanyl, 5-amino-valeroyl, 4-amino-cyclohexanoyl, 4-amino-butyroyl, 6-amino-caproyl and derivatives thereof. More particularly, the invention concerns polypeptides of formula (I) wherein “n” is 0 and with the formula: A-Lys-X-Lys-B; A, X and B being defined herein. Compositions containing at least one of said polypeptides and their use.
公开/授权文献
- US20110033507A1 Polypeptides KXK and Their Use 公开/授权日:2011-02-10
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