A signal transmission method in a multiple antenna system is described. The signal transmission method includes, upon receiving channel state information from a receiving end, estimating a channel according to the channel state information, determining a precoding matrix according to the estimated channel and modifying the signal of the transmitting end using the precoding matrix in a process of mapping a symbol of the signal to a subcarrier, and transmitting the signal to the receiving end. According to the present invention, pre-equalization of a transmission signal can cause a receiving end to perform coherent combination, reduce pilot density by decreasing unnecessary pilots, and reduce interference within a cell or between cells.