Computerized methods, systems, and computer-readable media are provided for establishing and managing a virtual network (V-net) and virtual machine (VM) switches that enable protected and isolated interconnections between members of the V-net. The V-net members include an originating network adapter that generates data packets addressed to a destination network adapter. Upon detecting data-packet generation, a source-side VM switch accesses a forwarding table associated with the V-net, ascertains a destination-side, VM-switch locator that corresponds to an identifier of the destination network adapter, and modifies the data packets to include the identifier. The forwarding table represents a mapping between the members of the V-net and VM switches located on respective nodes within the data center. In operation, the mapping enforces communication policies that govern data-packet traffic. Upon receiving the data packets, the destination-side VM switch restores the data packets and forwards them to the destination network adapter.