发明授权
US08410057B2 Method of inducing T cell apoptosis by administering Altered Peptide Ligand
有权
通过施用改变的肽配体诱导T细胞凋亡的方法
- 专利标题： Method of inducing T cell apoptosis by administering Altered Peptide Ligand
- 专利标题（中）： 通过施用改变的肽配体诱导T细胞凋亡的方法
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申请号： US13142471申请日： 2009-12-29
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公开(公告)号： US08410057B2公开(公告)日： 2013-04-02
- 发明人: Ariana Barbera Betancourt , Maria del Carmen Dominguez Horta , Norailys Lorenzo Perez , Gabriel Ramon Padron Palomares , Viviana Falcon Cama , Ivon Menendez Valdes
- 申请人： Ariana Barbera Betancourt , Maria del Carmen Dominguez Horta , Norailys Lorenzo Perez , Gabriel Ramon Padron Palomares , Viviana Falcon Cama , Ivon Menendez Valdes
- 申请人地址： CU Ciudad de la Habana
- 专利权人： Centro de Ingenieria Genetica y Biotecnologia
- 当前专利权人： Centro de Ingenieria Genetica y Biotecnologia
- 当前专利权人地址： CU Ciudad de la Habana
- 代理机构： Hoffmann & Baron, LLP
- 优先权： CU2008-0254 20081229
- 国际申请： PCT/CU2009/000009 WO 20091229
- 国际公布： WO2010/075824 WO 20100708
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/16 ; A61P43/00 ; A61P3/10 ; A61P7/12 ; A61P1/04
摘要：
The present invention is related with the field of the medicine, particularly with the use of an APL peptide or its analogues derived from the human heat shock protein of 60 kDa, for the manufacture of a pharmaceutical composition for the treatment of Crohn's disease, ulcerative colitis and diabetes mellitus type 1. This peptide is biodistributed into the gastrointestinal tract and also promotes the induction of apoptosis in activated intestinal lamina propria and peripheral blood T cells of patients with Crohn's disease. Furthermore, this peptide induces apoptosis in mononuclear cells of patients with diabetes mellitus type 1.
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