发明授权
US08410094B2 Amide compounds, their pharmaceutical compositions, their preparation method and their uses
有权
酰胺化合物，其药物组合物，其制备方法及其用途
- 专利标题： Amide compounds, their pharmaceutical compositions, their preparation method and their uses
- 专利标题（中）： 酰胺化合物，其药物组合物，其制备方法及其用途
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申请号： US13123455申请日： 2009-09-18
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公开(公告)号： US08410094B2公开(公告)日： 2013-04-02
- 发明人: Yaqiu Long , Xing Fan , Dongzhi Feng , Li Chen , Renhai Chen
- 申请人： Yaqiu Long , Xing Fan , Dongzhi Feng , Li Chen , Renhai Chen
- 申请人地址： CN Shanghai CN Shanghai
- 专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai Targetdrug Co., Ltd.
- 当前专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai Targetdrug Co., Ltd.
- 当前专利权人地址： CN Shanghai CN Shanghai
- 代理机构： Baker & Hostetler LLP
- 优先权： CN200810200896 20081008
- 国际申请： PCT/CN2009/001046 WO 20090918
- 国际公布： WO2010/040272 WO 20100415
- 主分类号： C07D451/04
- IPC分类号： C07D451/04 ; A61K31/46
摘要：
The present invention pertains to the field of pharmaceutical chemistry and discloses 8-(3-aminopropyl)-3-exo-8-azabicyclo[3.2.1]octane-3-amino amide compounds represented by formula I, the pharmaceutical compositions, the preparation method and the use thereof. Such compounds or pharmaceutically acceptable salts thereof can be used as an antagonist of CCR5 in preparing medicaments for treating diseases mediated by CCR5, particularly HIV infection, asthma, rheumatoid arthritis, autoimmune diseases and chronic obstructive pulmonary diseases (COPD).
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