- 专利标题: Compound having detrusor muscle-contracting activity and urethral sphincter muscle-relaxing activity
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申请号: US13377047申请日: 2010-06-09
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公开(公告)号: US08410281B2公开(公告)日: 2013-04-02
- 发明人: Kazuyuki Ohmoto , Akihiro Kinoshita , Hidekazu Matsuya , Hiroki Okada
- 申请人: Kazuyuki Ohmoto , Akihiro Kinoshita , Hidekazu Matsuya , Hiroki Okada
- 申请人地址: JP Osaka
- 专利权人: Ono Pharmaceutical Co., Ltd.
- 当前专利权人: Ono Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Osaka
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2009-139657 20090610; JP2009-256008 20091109
- 国际申请: PCT/JP2010/059771 WO 20100609
- 国际公布: WO2010/143661 WO 20101216
- 主分类号: A61K31/426
- IPC分类号: A61K31/426 ; C07D277/56
摘要:
Since a compound represented by formula (I) wherein all of the symbols are the same as defined in the specification, a salt thereof, a solvate thereof, a prodrug thereof, a mixture with a diastereomer thereof in an arbitrary ratio, or a cyclodextrin clathrate thereof have a contracting activity of bladder detrusor and a relaxing activity of urethral sphincter, they can ameliorate bladder contraction dysfunction and/or urethral relaxation dysfunction, and for example, are effective for underactive bladder. Additionally, the compound of the present invention has little risk of side effects on the urinary system, the circulatory system and the digestive system, and exhibits excellent pharmacokinetics, such as oral absorbability etc. Therefore, the compound of the present invention is useful as a superior agent for preventing, treating and/or ameliorating underactive bladder.
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