Certain examples provide systems, apparatus, articles of manufacture, and methods for medical device interface overlay. In an example, an article of manufacture includes an overlay for a clinical device touchscreen interface. The overlay includes a background surface formed to contact a touchscreen interface. The overlay also includes a plurality of touch areas formed in the background surface of the overlay device. Each of the plurality of touch areas is to provide a tactile boundary for a corresponding touchscreen interface function. The plurality of touch areas includes at least one of a plurality of openings and a plurality of recessed areas including a material thickness less than the material thickness of the background surface. The plurality of openings and the plurality of recessed areas allow user contact and interaction with the user interface underneath the overlay.