Aspects of a method and system for dynamically programmable serial/parallel bus interface may include performing in a first communication device coupled to a communication bus, attaching communication protocol information to a data signal for each data transaction with one or more other communication devices communicatively coupled to the communication bus. The one or more other communication devices may be controlled utilizing the attached communication protocol information. The communication protocol information may be dynamically adjusted and/or adaptively adjusted. The communication bus may be a serial or parallel communication bus. The serial communication bus may be a two-wire, three-wire, or four-wire bus. The attached communication protocol information comprises a multi-wire protocol, a 3-wire protocol, a Serial Peripheral Interface (SPI) protocol, a System Power Management Interface (SPMI), or an RF Bus protocol.