- 专利标题: Mesothelin antibody protein fusions and methods of use
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申请号: US13107624申请日: 2011-05-13
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公开(公告)号: US08435494B2公开(公告)日: 2013-05-07
- 发明人: Jeffrey A. Gelfand
- 申请人: Jeffrey A. Gelfand
- 申请人地址: US MA Boston
- 专利权人: The General Hospital Corporation
- 当前专利权人: The General Hospital Corporation
- 当前专利权人地址: US MA Boston
- 代理机构: Edwards Wildman Palmer LLP
- 代理商 Peter C. Lauro, Esq.; Elbert Chiang
- 主分类号: A61K49/00
- IPC分类号: A61K49/00 ; A61K39/00 ; A61K39/38
摘要:
The invention relates to fusion proteins comprising a stress protein fused with an engineered antibody or fragment that binds to mesothelin, or a stress protein fused with a biotin-binding protein in combination with a biotinylated engineered antibody or fragment that binds to mesothelin. The invention also relates to fusion proteins comprising a stress protein fused with an antibody binding protein in combination with an engineered antibody or fragment that binds to mesothelin. The invention also relates to fusion proteins comprising an engineered antibody or fragment that binds specifically to mesothelin fused in frame with a biotin binding protein. The invention also provides fusion proteins comprising an engineered antibody or fragment, that binds to mesothelin, fused with an antibody binding protein. The invention also relates to methods of using fusion proteins of the invention to induce an immune response to mesothelin and to treat disease.
公开/授权文献
- US20120134992A1 MESOTHELIN ANTIBODY PROTEIN FUSIONS AND METHODS OF USE 公开/授权日:2012-05-31