发明授权
- 专利标题： Polypeptides and biosynthetic pathways for the production of monatin and its precursors
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申请号： US12124014申请日： 2008-05-20
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公开(公告)号： US08435765B2公开(公告)日： 2013-05-07
- 发明人: Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , James R. Millis , John Rosazza , David P. Weiner , Lishan Zhao
- 申请人： Timothy W. Abraham , Douglas C. Cameron , Paula M. Hicks , Sara C. McFarlan , James R. Millis , John Rosazza , David P. Weiner , Lishan Zhao
- 申请人地址： US MN Wayzata
- 专利权人： Cargill, Incorporated
- 当前专利权人： Cargill, Incorporated
- 当前专利权人地址： US MN Wayzata
- 主分类号： C12N9/02
- IPC分类号： C12N9/02 ; C12N1/21 ; C12P13/22
摘要：
Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include in vitro and in vivo processes, and the in vitro methods include chemical reactions.
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