发明授权
US08435976B2 4-substituted pyridin-3-yl-carboxamide compounds and methods of use
有权
4-取代的吡啶-3-基 - 甲酰胺化合物及其使用方法
- 专利标题: 4-substituted pyridin-3-yl-carboxamide compounds and methods of use
- 专利标题(中): 4-取代的吡啶-3-基 - 甲酰胺化合物及其使用方法
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申请号: US12877202申请日: 2010-09-08
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公开(公告)号: US08435976B2公开(公告)日: 2013-05-07
- 发明人: Xiaojing Wang , Allen J. Ebens, Jr.
- 申请人: Xiaojing Wang , Allen J. Ebens, Jr.
- 申请人地址: CH Basel
- 专利权人: F. Hoffmann-La Roche
- 当前专利权人: F. Hoffmann-La Roche
- 当前专利权人地址: CH Basel
- 代理机构: Genentech, Inc.
- 代理商 Alex Andrus
- 主分类号: A01N43/00
- IPC分类号: A01N43/00 ; A01N43/40 ; A61K31/33 ; A61K31/497 ; A61K31/445 ; A61K31/44 ; C07D403/00 ; C07D405/00 ; C07D409/00 ; C07D417/00
摘要:
The invention relates to compounds of formula (I) which are useful as kinase inhibitors, more specifically useful as PIM kinase inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same, either alone or in combination, to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
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