发明授权
US08436001B2 Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
有权
吡唑-4-基 - 杂环基甲酰胺化合物及其使用方法
- 专利标题: Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
- 专利标题(中): 吡唑-4-基 - 杂环基甲酰胺化合物及其使用方法
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申请号: US13080762申请日: 2011-04-06
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公开(公告)号: US08436001B2公开(公告)日: 2013-05-07
- 发明人: Xiaojing Wang
- 申请人: Xiaojing Wang
- 申请人地址: CH Basel
- 专利权人: F. Hoffmann-La Roche AG
- 当前专利权人: F. Hoffmann-La Roche AG
- 当前专利权人地址: CH Basel
- 代理机构: Genentech, Inc.
- 代理商 Alex Andrus
- 主分类号: A61K31/497
- IPC分类号: A61K31/497 ; A61K31/506
摘要:
Pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein X is a thiazolyl, picolinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
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