发明授权
- 专利标题: Natriuretic peptide-mediated imaging of atherosclerotic plaque
- 专利标题(中): 利钠肽介导的动脉粥样硬化斑块成像
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申请号: US12454810申请日: 2009-05-22
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公开(公告)号: US08436140B2公开(公告)日: 2013-05-07
- 发明人: Pamela K. Woodard , Michael J. Welch , Geoffrey E. Woodard , Rafaella Rossin
- 申请人: Pamela K. Woodard , Michael J. Welch , Geoffrey E. Woodard , Rafaella Rossin
- 申请人地址: US MO Saint Louis
- 专利权人: Washington University
- 当前专利权人: Washington University
- 当前专利权人地址: US MO Saint Louis
- 代理机构: Zackson Law LLC
- 代理商 Saul L. Zackson
- 主分类号: C07K9/00
- IPC分类号: C07K9/00
摘要:
Tracers comprising an oligopeptide comprising a fragment of a natriuretic peptide, wherein the fragment comprises the sequence Arg-Ile-Asp-Arg-Ile (SEQ ID NO.: 1), and a signaling moiety, are disclosed. Further disclosed are methods of imaging atherosclerotic plaque by PET scanning or MRI using a tracer.
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