发明授权
US08440681B2 2-biphenylamino-4-aminopyrimidine derivatives as kinase inhibitors
失效
2-联氨基-4-氨基嘧啶衍生物作为激酶抑制剂
- 专利标题： 2-biphenylamino-4-aminopyrimidine derivatives as kinase inhibitors
- 专利标题（中）： 2-联氨基-4-氨基嘧啶衍生物作为激酶抑制剂
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申请号： US12675379申请日： 2008-08-27
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公开(公告)号： US08440681B2公开(公告)日： 2013-05-14
- 发明人: Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Xiaohui He , Badry Bursulaya , Christian Cho-Hua Lee
- 申请人： Thomas H. Marsilje , Wenshuo Lu , Bei Chen , Xiaohui He , Badry Bursulaya , Christian Cho-Hua Lee
- 申请人地址： BM Hamilton
- 专利权人： IRM LLC
- 当前专利权人： IRM LLC
- 当前专利权人地址： BM Hamilton
- 代理机构： Genomics Institute of the Novartis Research Foundation
- 代理商 Emily Tongco Wu
- 国际申请： PCT/US2008/074392 WO 20080827
- 国际公布： WO2009/032668 WO 20090312
- 主分类号： A61K31/4965
- IPC分类号： A61K31/4965 ; A61K31/497 ; C07D239/48
摘要：
The invention provides novel pyrimidine derivatives of formula (1) and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-1R) or anaplastic lymphoma kinase (ALK).
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