Invention Grant
US08440705B2 Compounds, compositions and methods of inhibiting alpha-synuclein toxicity
有权
抑制α-突触核蛋白毒性的化合物，组合物和方法
- Patent Title: Compounds, compositions and methods of inhibiting alpha-synuclein toxicity
- Patent Title (中): 抑制α-突触核蛋白毒性的化合物，组合物和方法
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Application No.: US11575481Application Date: 2005-09-16
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Publication No.: US08440705B2Publication Date: 2013-05-14
- Inventor: Susan L. Lindquist , Tiago Outeiro , Richard Labaudinière
- Applicant: Susan L. Lindquist , Tiago Outeiro , Richard Labaudinière
- Applicant Address: US MA Cambridge US MA Cambridge
- Assignee: Whitehead Institute for Biomedical Research,FoldRx Pharmaceuticals, Inc.
- Current Assignee: Whitehead Institute for Biomedical Research,FoldRx Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge US MA Cambridge
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2005/033050 WO 20050916
- International Announcement: WO2006/034003 WO 20060330
- Main IPC: C07D277/82
- IPC: C07D277/82 ; A61K31/428
Abstract:
Compounds and compositions are provided for treatment or amelioration of one or more symptoms of α-synuclein toxicity, α-synuclein mediated diseases or diseases in which α-synuclein fibrils are a symptom or cause of the disease. In one embodiment, the compounds for use in the compositions and methods are heteroaryl acylguanidines, heteroarylhydrazones, dihydropyridones, heteroaryl and aryl styryl ketones, and heteroarylpyrazoles.
Public/Granted literature
- US20080261953A1 Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity Public/Granted day:2008-10-23
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