- 专利标题： Triazole-substituted arylamides as P2X3 and P2X2/3 antagonists
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申请号： US13162378申请日： 2011-06-16
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公开(公告)号： US08440708B2公开(公告)日： 2013-05-14
- 发明人: Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
- 申请人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
- 申请人地址： US CA Palo Alto
- 专利权人： Roche Palo Alto LLC
- 当前专利权人： Roche Palo Alto LLC
- 当前专利权人地址： US CA Palo Alto
- 代理商 Robert C. Hall
- 主分类号： A61K31/41
- IPC分类号： A61K31/41
摘要：
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted triazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
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