Aspects of a method and system for mitigating interference among femtocells via intelligent channel selection are provided. In this regard, signals which may interfere with cellular communications between a femtocell and a cellular communication device may be detected via the femtocell. Based on the detection, the femtocell may be configured to transmit and/or receive signals on one or more frequencies and/or channels. The one or more frequencies and/or channels may be determined in the femtocell and/or in a network management entity. Detecting interfering signals and configuring the one or more femtocells may occur periodically, upon installation of a femtocell, upon power-up of a femtocell, and/or upon command from a network administrator. The results of the detection may be communicated to one or more other femtocells and/or to a network management entity.