发明授权
- 专利标题： Vaccine compositions and methods for treatment of mucormycosis and other fungal diseases
- 专利标题（中）： 疫苗组合物和治疗毛霉菌病及其他真菌病的方法
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申请号： US12661609申请日： 2010-03-19
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公开(公告)号： US08444985B2公开(公告)日： 2013-05-21
- 发明人: Ashraf S. Ibrahim , Brad J. Spellberg , Yue Fu , John E. Edwards
- 申请人： Ashraf S. Ibrahim , Brad J. Spellberg , Yue Fu , John E. Edwards
- 申请人地址： US CA Torrance
- 专利权人： Los Angeles Biomedical Research Institute at Harbor-ULCA Medical Center
- 当前专利权人： Los Angeles Biomedical Research Institute at Harbor-ULCA Medical Center
- 当前专利权人地址： US CA Torrance
- 代理机构： Jones Day
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K39/00 ; C07K16/00
摘要：
The present invention provides therapeutic compositions and methods for treating and preventing fungal disease or conditions including mucormycosis. The therapeutic methods and compositions of the invention include vaccine compositions having an FTR polypeptide or an antigenic fragment of the polypeptide; a vector including a nucleotide sequence that is substantially complimentary to at least 18 contiguous nucleotides of FTR sequence; an antisense; a small interfering RNA or an antibody inhibitor of FTR. The vaccine compositions of the invention can further include an adjuvant.