发明授权
- 专利标题： Use on minicircle vectors for cardiac gene therapy
- 专利标题（中）： 使用小环向量进行心脏基因治疗
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申请号： US12925483申请日： 2010-10-22
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公开(公告)号： US08445454B2公开(公告)日： 2013-05-21
- 发明人: Joseph Wu , Mark A. Kay , Mei Huang , Zhi-Ying Chen
- 申请人： Joseph Wu , Mark A. Kay , Mei Huang , Zhi-Ying Chen
- 申请人地址： US CA Palo Alto
- 专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人地址： US CA Palo Alto
- 代理机构： Bozicevic, Field & Francis LLP
- 代理商 Pamela J. Sherwood
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07H21/04 ; C07H21/02 ; C12N15/63
摘要：
Compositions and methods are provided for the treatment of an ischemic cardiovascular condition by providing a patient with a novel non-viral minicircle DNA vector comprising polynucleotide sequences that potentiate HIF-1 activity, including RNAi or antisense agents selective for proteins involved in HIF1 inactivation.
公开/授权文献
- US20110118333A1 Use on Minicircle vectors for cardiac gene therapy 公开/授权日：2011-05-19
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