发明授权
![Deuterated benzo[D][1,3]-dioxol derivatives](/docs/US/2013-05-28/US08450492B2/abs.jpg.600x600.jpg)
- 专利标题： Deuterated benzo[D][1,3]-dioxol derivatives
- 专利标题（中）： 氘代苯并[D] [1,3] - 二氧杂环戊烯衍生物
-
申请号： US12688466申请日： 2010-01-15
-
公开(公告)号： US08450492B2公开(公告)日： 2013-05-28
- 发明人: Roger Tung
- 申请人： Roger Tung
- 申请人地址： US MA Lexington
- 专利权人： Concert Pharmaceuticals, Inc.
- 当前专利权人： Concert Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Lexington
- 代理机构： McCarter & English LLP
- 代理商 Steven G. Davis
- 主分类号： C07D211/22
- IPC分类号： C07D211/22
![Deuterated benzo[D][1,3]-dioxol derivatives](/abs-image/US/2013/05/28/US08450492B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to an isotopologue of Compound 1 substituted with deuterium at the methylene carbon of the benzodioxol ring. The isotopologues of this invention selective serotonin reuptake inhibitors (SSRIs) and possess unique biopharmaceutical and metabolic properties compared to Compound 1. They may also be used to accurately determine the concentration of Compound 1 in biological fluids and to determine metabolic patterns of Compound 1 and its isotopologues. The invention further provides compositions comprising these deuterated isotopologues and methods of treating diseases and conditions that are responsive to increased neuronal serotonin transmission, alone and in combination with additional agents.
公开/授权文献
- US20100222589A1 DEUTERATED BENZO[D][1,3]-DIOXOL DERIVATIVES 公开/授权日：2010-09-02
信息查询
