What is disclosed is a novel system and method for generating a color inconstancy guide for use in spot color print applications. In a manner more fully disclosed herein, color inconstancy values are calculated for selected spot colors of interest using a color inconstancy metric. A color inconstancy guide is generated from the calculated color inconstancy values and their respective spot colors. Thereafter, when a user desires to render a job in a particular spot color, the associated color inconstancy value for that color can be obtained from the guide. In various embodiments, recommendations in the form of a suggested printer to use, a media type, a halftone screen, and other meaningful assistance can be provided for spot color selection that are less sensitive to varying illuminations for a given print/copy job. The present color inconstancy guide provides meaningful extensions in color quality and color reproduction in print/copy job environments.