The invention is an interface device and system for establishing an operating interface between an injector device and diagnostic imaging equipment. In one embodiment, the interface device may permit an operator to concurrently operate and control the injector device and the imaging equipment. The interface device may permit the injector system and the imaging system to communicate information regarding their current and future operational status with each other. The interface device may be used to synchronize the operation of the imaging equipment and the injector device. In one embodiment, the injector device and the imaging equipment may be able to communicate with each other directly or through the interface device via a communications protocol comprising binary logic signals. The binary logic signals may comprise one or more of a low strength signal, a high strength signal, an oscillating signal that oscillates between low and high signal strength, and combinations thereof.