- 专利标题： Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
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申请号： US13390538申请日： 2010-08-23
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公开(公告)号： US08455533B2公开(公告)日： 2013-06-04
- 发明人: Tesfaye Biftu , Ping Chen , Danqing Feng , Xiaoxia Qian
- 申请人： Tesfaye Biftu , Ping Chen , Danqing Feng , Xiaoxia Qian
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Janet E. Fair; John C. Todaro
- 国际申请： PCT/US2010/046270 WO 20100823
- 国际公布： WO2011/028455 WO 20110310
- 主分类号： A61K31/4162
- IPC分类号： A61K31/4162 ; C07D231/00
摘要：
The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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