- 专利标题: Stabilized liquid anti-RSV antibody formulations
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申请号: US13481640申请日: 2012-05-25
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公开(公告)号: US08460663B2公开(公告)日: 2013-06-11
- 发明人: Cynthia N. Oliver , Erica Shane , Benjamin S. Isaacs , Christian B. Allan , Stephen T. Chang
- 申请人: Cynthia N. Oliver , Erica Shane , Benjamin S. Isaacs , Christian B. Allan , Stephen T. Chang
- 申请人地址: US MD Gaithersburg
- 专利权人: MedImmune, LLC
- 当前专利权人: MedImmune, LLC
- 当前专利权人地址: US MD Gaithersburg
- 代理机构: Jones Day
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; A61K39/42
摘要:
The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention.
公开/授权文献
- US20120321616A1 STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS 公开/授权日:2012-12-20
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