A method of moisturizing while decolonizing mammalian tissue, the method comprising applying a multi-valent cationic antiseptic composition to the tissue, and applying a moisturizer composition to at least a portion of the same tissue; wherein the mammalian tissue is oral tissue of a subject; wherein the multi-valent cationic antiseptic is other than a metal ion; and wherein the applied compositions essentially exclude any component which causes a precipitate when combined with a multi-valent cationic antiseptic contained in the multi-valent cationic antiseptic composition when tested according to Test Method F, and/or wherein the moisturizer composition is such that a log reduction in the number of viable bacterial cells of at least 2 is provided when 106 cfu of Pseudomonas aeruginosa are combined with a mixture 1.1 g of the moisturizer composition and 1.5 g of the multi-valent cationic antiseptic composition containing 0.12 weight percent of the multi-valent cationic antiseptic according to Test Method B; an oral care kit comprising a composition comprising the multi-valent cationic antiseptic and the moisturizer composition; and a method of moisturizing oral tissue of a patient requiring intubation using the moisturizer composition and an endotracheal tube coated or impregnated with a cationic antiseptic are provided.