Various methods and structures related to clock distribution for flexible channel bonding are disclosed. One embodiment provides a clock network in physical media attachment (“PMA”) circuitry, a specific type or portion of system interconnect circuitry, arranged in pairs of channel groups. In one embodiment, clock generation circuitry blocks (“CGBs”) in each pair of channel groups receives outputs of multiple phased locked loop circuits (“PLLs”) which can be selectively utilized by the CGBs to generate PMA clock signals. In another embodiment, the CGBs can also select output of a clock data recovery (“CDR”)/transmit PLL circuitry block in one of the channels of a channel group of the pair of channel groups. In one embodiment, first groups of connection lines couple circuitry in a channel group pair such that a designated CGB in each channel group pair can provide clock signals to one or more of the channels in the channel group pair. In one embodiment, second groups of connection lines connect channels in one channel group pair to channels in other channel group pairs such that one or more channels across the channel group pairs can receive a clock signal generated by a CGB in a designated channel. These and other embodiments are described more fully in the disclosure.