A method of operating a transmission of a vehicle drive-train that comprises frictional shifting elements and an interlocking shifting element. In the neutral operating condition of the transmission, and in the case of an operating condition variation of the vehicle drive-train in which, when it is required to establish the force flow in the transmission, the interlocking shifting element is to be changed from a disengaged to an engaged operating condition, by increasing the transmission capacities of at least two frictional shifting elements which have to be engaged for producing the force flow, a rotational speed difference in the area of the interlocking shifting element is determined, and a drive torque of a drive machine is adjusted to a level that brings the speed difference within a predefined range at which the interlocking shifting element is approximately synchronized and can therefore be engaged.