发明授权
- 专利标题： Use of spiro-oxindole compounds as therapeutic agents
- 专利标题（中）： 使用螺 - 羟吲哚化合物作为治疗剂
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申请号： US12445264申请日： 2007-10-12
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公开(公告)号： US08466188B2公开(公告)日： 2013-06-18
- 发明人: Mikhail Chafeev , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Rajender Kamboj , Duanjie Hou , Shifeng Liu , Mehran Seid Bagherzadeh , Serguei Sviridov , Shaoyi Sun , Jianyu Sun , Nagasree Chakka , Tom Hsieh , Vandna Raina
- 申请人： Mikhail Chafeev , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Rajender Kamboj , Duanjie Hou , Shifeng Liu , Mehran Seid Bagherzadeh , Serguei Sviridov , Shaoyi Sun , Jianyu Sun , Nagasree Chakka , Tom Hsieh , Vandna Raina
- 申请人地址： CA Burnaby, BC
- 专利权人： Xenon Pharmaceuticals Inc.
- 当前专利权人： Xenon Pharmaceuticals Inc.
- 当前专利权人地址： CA Burnaby, BC
- 代理机构： Seed IP Law Group PLLC
- 国际申请： PCT/US2007/081247 WO 20071012
- 国际公布： WO2008/060789 WO 20080522
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/5377
摘要：
This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.
公开/授权文献
- US20110172282A9 USE OF SPIRO-OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS 公开/授权日：2011-07-14