Invention Grant
- Patent Title: Use of spiro-oxindole compounds as therapeutic agents
- Patent Title (中): 使用螺 - 羟吲哚化合物作为治疗剂
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Application No.: US12445264Application Date: 2007-10-12
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Publication No.: US08466188B2Publication Date: 2013-06-18
- Inventor: Mikhail Chafeev , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Rajender Kamboj , Duanjie Hou , Shifeng Liu , Mehran Seid Bagherzadeh , Serguei Sviridov , Shaoyi Sun , Jianyu Sun , Nagasree Chakka , Tom Hsieh , Vandna Raina
- Applicant: Mikhail Chafeev , Sultan Chowdhury , Robert Fraser , Jianmin Fu , Rajender Kamboj , Duanjie Hou , Shifeng Liu , Mehran Seid Bagherzadeh , Serguei Sviridov , Shaoyi Sun , Jianyu Sun , Nagasree Chakka , Tom Hsieh , Vandna Raina
- Applicant Address: CA Burnaby, BC
- Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee Address: CA Burnaby, BC
- Agency: Seed IP Law Group PLLC
- International Application: PCT/US2007/081247 WO 20071012
- International Announcement: WO2008/060789 WO 20080522
- Main IPC: A61K31/40
- IPC: A61K31/40 ; A61K31/5377
Abstract:
This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.
Public/Granted literature
- US20110172282A9 USE OF SPIRO-OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS Public/Granted day:2011-07-14
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