发明授权
US08466284B2 Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
失效
一些2-吡嗪酮衍生物及其作为嗜中性粒细胞弹性蛋白酶抑制剂的用途
- 专利标题： Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
- 专利标题（中）： 一些2-吡嗪酮衍生物及其作为嗜中性粒细胞弹性蛋白酶抑制剂的用途
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申请号： US12740136申请日： 2008-11-05
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公开(公告)号： US08466284B2公开(公告)日： 2013-06-18
- 发明人: David Chapman , Martin Lindsjö , Hans Lönn , Michael Lundkvist , Magnus Munck AF Rosenschöld , Antonios Nikitidis , Debra Ainge , John Pavey
- 申请人： David Chapman , Martin Lindsjö , Hans Lönn , Michael Lundkvist , Magnus Munck AF Rosenschöld , Antonios Nikitidis , Debra Ainge , John Pavey
- 申请人地址： SE Sodertalje
- 专利权人： Astra Zeneca AB
- 当前专利权人： Astra Zeneca AB
- 当前专利权人地址： SE Sodertalje
- 代理商 Kate Kizer
- 国际申请： PCT/SE2008/051263 WO 20081105
- 国际公布： WO2009/061271 WO 20090514
- 主分类号： C07D241/02
- IPC分类号： C07D241/02
摘要：
The invention provides certain novel compounds as listed in the specification and pharmaceutically acceptable salts thereof and particular Forms thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase. The present neutrophil elastase inhibitors include 6-[1-(4-Cyanophenyl)-1H-pyrazol-5-yl]-5-methyl-3-oxo-4-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide:
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