Peritoneal dialysis systems are provided by the present disclosure. In a general embodiment, a peritoneal dialysis system includes a cycler, a disposable cassette operable with the cycler, a supply bag connected to the disposable cassette, a supply connector, a supply line extending from the disposable cassette, a patient connector in fluid communication with a patient's indwelling catheter, a device to connect the supply connector to the patient connector, and a housing around the device. The housing includes a plurality of ultraviolet (“UV”) light-emitting diodes (“LED's”) for directing energy towards at least one of the supply or patient connectors. The LED's are configured to deliver about 200 milliJoules in a period of about a minute.