Methods and apparatus are provided for intercepting a client-server communication connection in a computing environment. A first network intermediary configured to facilitate optimization of client-server transactions may be installed in a path of communications between the client and the server. A second network intermediary configured to cooperate with the first network intermediary is not in the path of communications between the client and the server. The first network intermediary intercepts a connection request from the client and forwards a modified request toward the server. A module within the server intercepts the connection request and redirects it to the second network intermediary. The client-server connection is thus split-terminated at the two network intermediaries, which establish cooperative sessions between themselves and with the client and with the server.