发明授权
- 专利标题： Insulinotropic complex using an immunoglobulin fragment
- 专利标题（中）： 使用免疫球蛋白片段的胰岛素复合物
-
申请号： US12523050申请日： 2008-01-04
-
公开(公告)号： US08476230B2公开(公告)日： 2013-07-02
- 发明人: Dae Hae Song , Chang Ki Lim , Tae Hun Song , Young Hoon Kim , Se Chang Kwon , Gwan Sun Lee , Sung Youb Jung , In Young Choi
- 申请人： Dae Hae Song , Chang Ki Lim , Tae Hun Song , Young Hoon Kim , Se Chang Kwon , Gwan Sun Lee , Sung Youb Jung , In Young Choi
- 申请人地址： KR Hwaseong-si
- 专利权人： Hanmi Science Co., Ltd
- 当前专利权人： Hanmi Science Co., Ltd
- 当前专利权人地址： KR Hwaseong-si
- 代理机构： Sughrue Mion, PLLC
- 优先权： KR10-2007-0001662 20070105
- 国际申请： PCT/KR2008/000061 WO 20080104
- 国际公布： WO2008/082274 WO 20080710
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K39/395 ; A61P5/50
摘要：
The present invention relates to an insulinotropic peptide conjugate having improved in-vivo duration of efficacy and stability, comprising an insulinotropic peptide, a non-peptide polymer and an immunoglobulin Fc region, which are covalently linked to each other, and a use of the same. The insulinotropic peptide conjugate of the present invention has the in-vivo activity which is maintained relatively high, and has remarkably increased blood half-life, and thus it can be desirably employed in the development of long acting formulations of various peptide drugs.
公开/授权文献
信息查询
IPC分类:
