发明授权
- 专利标题: Cyanopyrroles
- 专利标题(中): 青色
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申请号: US12915211申请日: 2010-10-29
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公开(公告)号: US08476262B2公开(公告)日: 2013-07-02
- 发明人: Mark A. Collins , Valerie A. Mackner , Jay E. Wrobel , Lin Zhi , Todd K. Jones , Christopher M. Tegley , James P. Edwards
- 申请人: Mark A. Collins , Valerie A. Mackner , Jay E. Wrobel , Lin Zhi , Todd K. Jones , Christopher M. Tegley , James P. Edwards
- 申请人地址: US NJ Madison
- 专利权人: Wyeth LLC
- 当前专利权人: Wyeth LLC
- 当前专利权人地址: US NJ Madison
- 代理机构: Howson & Howson LLP
- 主分类号: A61K31/535
- IPC分类号: A61K31/535
摘要:
This invention provides a progesterone receptor antagonist of formula 1 having the structure wherein, T is O, S, or absent; R1, and R2 are each, independently, hydrogen, alkyl, substituted alkyl; or R1 and R2 are taken together form a ring and together contain —CH2(CH2)nCH2—, —CH2CH2CMe2CH2CH2—, —O(CH2)pCH2—, —O(CH2)qO—, —CH2CH2OCH2CH2—, or —CH2CH2NR7CH2CH2—; n=1-5; p=1-4; q=1-4; R3 is hydrogen, OH, NH2, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or CORA; RA is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R4 is hydrogen, halogen, CN, NH2, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R5 is hydrogen, alkyl, or substituted alkyl; R6 is hydrogen, alkyl, substituted alkyl, or CORB; RB is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R7 is hydrogen or alkyl; or a pharmaceutically acceptable salt thereof.
公开/授权文献
- US20110039839A1 Cyanopyrroles 公开/授权日:2011-02-17