An interface for use in a local device includes a transmitter portion programmably configurable to at least three data rates, a receiver portion programmably configurable to those at least three data rates, and an automatic speed negotiation module operatively connected to the transmitter portion and the receiver portion to configure the transmitter portion and the receiver portion for communication with a remote device at a single data rate that is a best available one of those at least three data rates. The date rate can be adjusted by adjusting transmitter data path width and receiver data path width, adjusting a frequency of said transmitter data path and said receiver data path, and oversampling. Byte serialization or deserialization can be enabled or disabled to alter the width of the data, depending on the data rate, for transfer to/from the remainder of the local device.