A distribution method and an operation method and system of application system in mobile communication network are disclosed. The methods are adapted to mobile information field, which include: a mobile communication terminal establishes connection with an application system distribution platform through a mobile communication network; the mobile communication terminal uses the application system by an application system human-computer interaction module installed on the application system distribution platform; the application system and the human-computer interaction module run; an output process module of the application system distribution platform obtains a screen display image data of the human-computer interaction module, and sends it to the mobile communication terminal; the mobile communication terminal displays the screen display image of the human-computer interaction module, and sends an input information to the human-computer interaction module; step C and step E are repeated until the mobile communication terminal exit from the operation of the application system. The present invention can make an application system distributed on a mobile communication terminal, therefore, the network requirement is little, and the experience of the user is high.