Methods and apparatus are provided for adaptation of continuous time-decision feedback equalizers with programmable adaptation patterns. A continuous time-decision feedback equalizer is adapted by obtaining at least one programmable signature pattern that triggers adaptation of one or more of a pole and a gain of the continuous time-decision feedback equalizer; detecting the at least one programmable signature pattern in an incoming signal; and adapting one or more of the pole and the gain of the continuous time-decision feedback equalizer when the at least one programmable signature pattern is detected in the incoming signal. The programmable signature pattern can be selected to ensure an unambiguous direction of change in an error sample when a corresponding one of the pole and the gain are modified.