The present invention discloses a self-calibration method for an electric power steering system, which can self-calibrate the sensors to a normalized state to prevent from signal distortion, whereby to maintain stable steering sense of the driver and promote robustness and performance of the EPS system. The self-calibration method includes a signal offset compensation tactic and a zero-point signal self-calibration tactic. The present invention determines whether to undertake self-calibration according to judgement tactics, including a sensor power supply judgement tactic, a sensor correctness judgement tactic, and a self-calibration triggering condition. The self-calibration method can increase the correctness of sensors, maintain the original steering-assisting function and promote robustness of the EPS system.