A cutter-tooling assembly has a tool holder and a cutter. The tool holder has an inserted section and a through hole axially formed through the inserted section. The through hole has a fixing segment. The fixing segment has an inner surface and multiple recesses formed around the inner surface of the fixing segment at intervals. The cutter is inserted into the through hole of the tool holder and has a fixing end. The fixing end has an outer surface and multiple corners formed on the outer surface of the fixing end and abutting the recesses. Because the fixing segment has the multiple recesses which the corners of the cutter abut, the combination of the recesses and the corners can prevent a relative rotation between the tool holder and the cutter and make the cutter securely connected with the tool holder.