发明授权
US08486642B2 Method of synthesizing 1,3-cyclohexadione derived reagents useful for detection or isolation of sulfenic acid-containing compounds
有权
合成可用于检测或分离含亚磺酸化合物的1,3-环己二酮衍生试剂的方法
- 专利标题： Method of synthesizing 1,3-cyclohexadione derived reagents useful for detection or isolation of sulfenic acid-containing compounds
- 专利标题（中）： 合成可用于检测或分离含亚磺酸化合物的1,3-环己二酮衍生试剂的方法
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申请号： US12861529申请日： 2010-08-23
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公开(公告)号： US08486642B2公开(公告)日： 2013-07-16
- 发明人: Leslie B. Poole , S. Bruce King , Jacquelyn S. Fetrow
- 申请人： Leslie B. Poole , S. Bruce King , Jacquelyn S. Fetrow
- 申请人地址： US NC Winston-Salem
- 专利权人： Wake Forest University Health Sciences
- 当前专利权人： Wake Forest University Health Sciences
- 当前专利权人地址： US NC Winston-Salem
- 代理机构： Myers Bigel Sibley & Sajovec, P.A.
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; C07C229/56 ; C07D311/16
摘要：
The present invention provides a method of synthesizing compounds of Formula I: wherein: R1 is a label (e.g., a detectable groups; an anti-tumor agents); L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. the compounds are useful for, among other things, identifying cysteine sulfenic acids in proteins and monitoring oxidative damage in proteins and cells.
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